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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72f9ca14a7b84bff838c4e73cd934990dba4b1e7dcdda47a5bb10b34d27acae7' 
  AND token = 'GmpDv+Lqbeus8B1Sti8rpsnMYAV2XLX0KE2KeYIY7vk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}