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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b0d4b83fa25a37d654ec40306c297690714e438d65f22143354aaadb94ace97a' 
  AND token = '+iP7nLz+3NODMJpOWGMFCmUBEU0GAvLJ/llf6OAuT2M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}