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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d7b9166eb413bced01fcb5197e459c016a6c2606ea1214873b7a315d9b6c182' 
  AND token = '5An5G5SkQ9Y3uktEsvR2GxIVkHx3U8SoiPeU4+HQeCc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}