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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd7f2e8407c81b9e6a0d8d10b5637dde5a4cc7b7129bf61b7fd4b2825a0cb8f66' 
  AND token = 'DQebtnCt/K4QFRh7L9L/j1Be8AR12dLPxOVRlZeDmyY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}