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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c6a7ae0bd44b7f4c19b7377e1cfd53779f9503c5cdde1a6509ddc78444c81641' 
  AND token = '1GY9+HGOYfi1+2PRcdD3FPLKQIm3LIn2VeTGYe3a3tM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}