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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8580fec4ed372590e734a323af185c001673d3603a282dde5a1b32a98741a113' 
  AND token = 'cT22hPVZsfHcWrk+CNi6m3Qy21u0EB1tXKFfs5mFISc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}