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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a66303a73dd8df730b3178fa992e7661c4cb2823313a9c88f5fcbc0888520e9' 
  AND token = 'QqhMHpuwg+Ycn9iuL1MSvTabLaXK8mNmrjhEaVur0OY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}