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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52f38b0b849c49b31cf4df9701626ac5ff2413421dc23de6c3320b583da3b423' 
  AND token = 'RMcmaGnnRrHaQow3+/liMbnfYOnrjrrPyRyU8eYvz3g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}