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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '578d8f3d279fdadc6302f4e45fed9cd87d19559a9358394ece3dfbe783477d4f' 
  AND token = 'cV48nVZm2ObFOUoaLR9GNxtUfn7F22ykGtzYpcdILuY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}