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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '04843437542ab2bb08f8ea5b206e657ecb09ec6d8dc560ce82446680f451a857' 
  AND token = 'MeZR1GYZCSrSnnirtXk7pEdxteAkFtiUpQiFw5xz+XY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}