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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e43e3647c4752680fbe719ebff754b2d0e4b5af08eace5fb7c500f0be898ca57' 
  AND token = 'mML41e0Y2uEhR3qcFLWcOEPEtLxCfVjFfJ3NlxP6tss=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}