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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18a51c9b6eddfa01d423459292e821b24e159d228476d0d25ce29fdd808520b6' 
  AND token = 'KdKoSCZk/wtJJCm+6K+mXh7GNBbbaR6uotxZaK1rZFQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}