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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b0597765a3e5fd582e1b9ae256f5b3fd9a2f9165e4b72e66d7acb4400c627ef' 
  AND token = 'nMo4dTIdnlECGuwTNzQt42cu4/2HYIe2cXRTmXp/i2M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}