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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6159cdb709f02696c676ab5431d6fe5d4f43675ac6251716e69d25e63d0a6fe7' 
  AND token = 'tC+iZo2/pJ2dykqfVVvTCdUdnJVWT97Dp4Sn7WUpBkk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}