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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '781b9f6a2750e526121845feac6d626ce8d28ef1b216ca93709912b2ac74778d' 
  AND token = '1QmHTRiDV33bF9x+SH6v8Y0bpMr2J38Mkk7ty3/XAOg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}