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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7ea501a4efe84160806ed5fe717aa78df9ae157ec4041f4e7cd3ba180cc9e3c5' 
  AND token = 'QpkJUkGozOC2RU0D5gOKJNAODHuNSY1zbjJ9ys3R3oE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}