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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd446b51b2c37e1bd4e479aae1f430c297881b2e3e67f8ce271fc858a23851718' 
  AND token = 'k6ox2POE8GIr6dAeneZH3RCPYQZfD5BK13KQbj77/68=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}