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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43d00ce4fc774564a45fd136c0b7e882608fd526036c06d2d0fae116fb0472fb' 
  AND token = 'rrrjCFVso4EF6NGpuHnwxuhVh/SgEE3zGCS0Rt/TmSo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}