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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6de303c168946c37439de9a6da7caf582ddfd009907b06fc5a9f208cdead06ab' 
  AND token = 'JXL/ViorZ5l6YLNt/dhzn8alT+XDnAJb+9E3Q/tWSrY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}