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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49f45f138c308b4219e212145c224fcad0e885077cfd9af1ce9db9746ebad270' 
  AND token = 'uOTfryxdwWrgOjthoznPS2duh32DtUiDd675wl2J5t8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}