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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4263f9731f4745d64677b4663f569cd909fb763d1f86a1753d54c4a6e8a5613' 
  AND token = 'XtnaOO6Gop5qPqjS0NN9NA5QAiZ7NZPgAWeOyxxuSVE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}