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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd53975c142849e8aca5018e32d2e9f0091c1e79335cf19daff17a429ff7bc45d' 
  AND token = 'NEMh25NzGuYDNiHfZu+BoyFmwclA0qV9HCBl9W9CzG8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}