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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52d224e39d2c5ef41995e1072a0d135b201bc664d8331225ddae8775f18a1c71' 
  AND token = 'WmQFlFGjcLh+TgDUyy7RhmMerkiBFMA6zjwXtodoiyg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}