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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '459e863cc8bc27e2cf1e808735aa7d858a349447ac55397d633ae46a6b1bbcf1' 
  AND token = 'jI5Ztwlo3eijY6AcSshDcjmOpP/lb6glXMMUT21Y+i4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}