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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65171c55d61856ad55a6a04d2437dc7be6e214e8261ada6df21ab5304c398142' 
  AND token = 'O1denP17tZ4rKSZ11aUUKABVKUGrmIbK+iwuY8t9wwg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}