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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5253a00be4f163517cc858e70b5295871f1156ac23b05e5667c0dbb45ded449b' 
  AND token = 'Ayf1TSZahlsdYIZALGTqcaYRC4a24DEUzZnwEFLc1Rw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}