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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2de259cbb18b8ca8d139f4dd202d3ff0e8b52a331028ecbb161ea2d32c40a74b' 
  AND token = 'Q1jwak+VgsxUs8PnS1s78/H5nW+pO1zB8wU0eFEkaCc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}