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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6cd7d1bd8402f6a45d97b144e533560ad1e0bc80fbbc7030393488f4ba630049' 
  AND token = 'jFsmsRC+vx/UTOrnPEx+dD26zYZ4IxKTzOSJIFECEGk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}