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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '246fd380dd6937490e24449bf84d7f16a2a1901fb10422ba4e7ebd517baffe0e' 
  AND token = 'FUIPMtlTQaCgrDYi5kcTQ8Jj+0mTeOHdgbubMUPBtMk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}