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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '34e3cf27b14d14a23be517aa5a1f45afa8ecb87151d8a1366525618dc4f3bfb7' 
  AND token = 'mAD5xQaaR1h0o+C0NVlzZAhTkqWnSVtFapeNuRiAOY8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}