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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4dc1c18a135eb1068e1493eedb98d450e710935c5c7b07987e50e6764d0fa129' 
  AND token = '/ekFQ7HWDp/BiebhtQeGOsBgH7g5hf+Z0O/Wz0rh4cg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}