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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46ded7c3e64691406f5f2e484a20a0a39c4118f3ce4f626c73758a741b85ecfe' 
  AND token = 'mHfzxptp3ArhNNSeFeqDaxrzKxN70zNcaftG5ZbbBaY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}