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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '460306a64ec921f169444dd423a04256a6a4979cbaacd6ad06c7603271a0a5e1' 
  AND token = 'i4EY1wFfvtojzvvo1kkLzz33IW/uykBIsxfwurS0W5A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}