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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '601d5682dc13470a8f146089302c36b36405804098b6c83e46d56641266d79d9' 
  AND token = 'uIJk4CWNA8gcsr+6LB8oHBNWQp5XIo+rbXUARyIi7vY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}