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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6781f8e8414ee278e3ced126b9a1e11a8af68751d6da3e0d71173b81eb428109' 
  AND token = 'iE/j8vWhTSBrwod/FdbG06wspPREQkUd9BDj2AJYLHo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}