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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b187f26348e3b9d5e0dd83eafbbfa2054b86affe84a7f7e42599d0c57642b57' 
  AND token = 'pOo/Lr35+gIH5bzNuQwa0glryZfEhijQiI+RRpC7Xeo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}