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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '818f8afbcd3a284636e9e413a71a9f61793cb287b9a6bd672c637df224140d82' 
  AND token = 'ceYlZDmP8mBaaK2Zk2UsGsbT36xKrsjMNDJnnNh2Crc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}