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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '23746272996aa25c108d7c20235061f9aa0d008014778c1a37c25ed65c5191c2' 
  AND token = 'XCHV3Mc5LHTG4cnZsTVxBAj0lQgkSr8xGfbWZNLcqd4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}