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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e820fc5981512b37276a174082ccef2e362192e4edbf136a01087e24be81218' 
  AND token = '38ne99D/DNJg+o3Xc+zXwRT3b3rBnwbt+Z6rGKDhTKo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}