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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '74b41d7483f8fa1413d45f1285564d249f6d11a995092c562acdbac7f1a87601' 
  AND token = 'AE2KO91HWP48KKsXA/PTKm6OjmaxreLDz0c6EU3H2w4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}