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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '39b307c9062aff12fbd97b4459b77ad571b578b6dffb083dd4440557968a6af0' 
  AND token = 'Z0/KUxv+ML+dMSFFlrVqlY1lZF9i4uDEmcUr8DqALLk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}