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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c800e4b25f2c2a34627f4c019cb448a88a5ec9795b53cada48bc7906fc195d33' 
  AND token = 'cX6p5+ATseA8mTIbEUKE3+DmwqmHbjqaKfoi+Jn4TaI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}