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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '54181902a38be2d66de8bc65fb2b11875a8fa29fdec941d5e6dbd646577e69d0' 
  AND token = '7jLmuUoTRQNEh4sotz9yPDFk5md+3BtNGzWEDn/O5n8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}