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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e8409d7c2800a3616eeb3035b4799bddc66a69d18eb731597b29d8f2f6ab442' 
  AND token = '6ip7i6vxTUB9kWAeKvtd/jHFBSex4wmvjXj9Nqm4y/s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}