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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8f4ad824587102349015db6990f9a3aec878acc529438a2acef300c16c3e8423' 
  AND token = 'yjGirIXQCTL7+bNHs69NUDiAIE5KwzdbcZb2nRl/ylc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}