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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1621ce2bbc2d747a28d29a2cadcd3c1f02ef8fa296d87dc58b66021c6cac19f2' 
  AND token = 'AMeG9W+oFYibpjeSqw6sm/Z4wgf7xu1/pZDcO6/JBcA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}