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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9558d49680e6147099ee5f19f28edf6c2a3e220f37cf6115628fe054a1a5f3b0' 
  AND token = 'cvoCnt3GLe+uw6fr+7HneRxPlI2Fnt15MZ2IXRzVM40=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}