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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e355bef1f790a8c2fbdf3d8e02e69de6098a6f5e561890e48875e852f4ee749' 
  AND token = 'ad7RSGSL1T8G/IvAyrrHiDqNd4Lbs34hJPo7MZqOlxw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}