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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '257123266cb0f8c2acfed64e5e8b1d80bef70b38ea0c7ebdc8eabfa7148ca161' 
  AND token = '33ddtWI1JODxx2Lc7IWJAqvYnIDXN+VhF3h2fJ7a9vQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}