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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1ad26cf9bf647ba439599c6d2b5a687dab8dd00388c116f84d5197605e913346' 
  AND token = 'TC1DdxjKpbH+C7eLfK6islQINygB51TYQ/aWZ1msj58=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}